Wed Nov 28, 2018 08:32 AM
I have a question that makes the results of the senolytic drugs seem counterintuitive. When senolytic drugs cause senescent cells to die, other (younger) cells need to divide and take the place of the dead cells. This cell division causes telomere shortening, and thus possibly creating new senescent cells. How is it that the process of killing senescent cells is not self defeating if new senescent cells are being created?
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