Mon Apr 19, 2021 05:00 PM

This is a follow up to the Mike Lustgarten’s video post about: https://www.youtube.com/watch?v=XaxY7LpuSFo I read the paper and created a calculation to translate the mmol/kg/day quantity to g/kg/day quantity. Basically how many grams per day you should take to replicate the experiment on yourself. I’d appreciate anyone checking my calculations. Though it’s been a very long time since I’ve taken Chemistry in school, I used this page to check my work on calculating molar mass to grams: https://planetcalc.com/6777/ I put in the compound formula, select moles to grams, enter the quantity in moles (not millimoles), select 4 digits after decimal point, then click calculate.

But first I calculate my weight in kilograms from pounds (~ 74.8 kg).

From the paper: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ctm2.372 “OAs were provided capsules of glycine (1.33 mmol/kg/day)” “and cysteine (0.81 mmol/kg/day, provided as Nacetylcysteine [NAC]) prepared by a licensed pharmacist,” “and replenished every 4-weeks for 24-weeks.” (What does this mean “replenished every 4-weeks for 24-weeks”?)

1.33 mmol = 0.00133 mol and 0.81 mmol = 0.00081 mol Glycine C₂H₅NO₂ (C2H5NO2) has molar mass = 75.067 N-acetylcysteine (C5H9NO3S) has molar mass = 163.197

Experiment quantity in mols (Xmol) * molar mass * body mass in kg quantity (mol/kg/day) * molar mass (g/mol) * body mass (kg) = suggested use in grams Glycine C2H5NO2: 0.00133 * 75.067 * 74.8 ~= 7.5 g N-acetylcysteine C5H9NO3S: 0.00081 * 163.197 * 74.8 ~= 9.9 g

There’s more to this though. I’m thinking there is a linear relationship in the loss of Glycine and N-acetylcysteine between the age groups. It was a small sample size, but: “Eight OA (five women, three men; 71–80 years) and eight gender-matched young adults (YAs) (21–30 years) who volunteered to participate in the study were recruited and enrolled” So I averaged them to be 25 y/o and 75 y/o age groups. Since I’m not 75 year old, maybe I need a smaller quantity, so here is another calculation based on my age. Proportion in grams based on age = (age – 25) / (75 – 25) For me it would be: (45 – 25) / (75 – 25) = 0.4

Glycine C2H5NO2: 7.5 * 0.4 = 3 g N-acetylcysteine C5H9NO3S: 9.9 * 0.4 = 3.96 g (~ 4 g)

Again, I used my own body mass and age to calculate the grams per day I should take. Your suggested/calculated quantity may be different. Most supplements are going to be in the quantities of 500 mg to 1000 mg, so you’ll probably have to round it.

---

ADVERTISEMENT: Quickly import all of your Facebook content into your blog